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Vish Nene joined ILRI as the Director of the Biotechnology Theme on 1st April 2009 and was previously with the Institute for Genome Sciences, University of Maryland, The Institute for Genomic Research & J. Craig Venter Institute, USA. He has a broad range of research interests that converge on developing improved or novel methods of disease control and in the use of whole genome sequence data and genomics technologies to underpin laboratory research. Vish has more than 20-years’ experience in molecular parasitology and 8 years in genomics research. He obtained his graduate and PhD degree and post-doctoral training in the UK. He has published extensively, participated in several training workshops, presented research findings at many conferences and mentored high school, graduate and post-graduate students.OPERATING PROJECTS 1. Improving Disease Control and Product Safety 2. Improving Animal Genetic Resources Characterization 3. Improving Utilization of Farm Animal Genetic Resources 4. GEF West Africa 5. Bioinformatics 6. Animal Unit 7. Biological Services, Vector Services, Haematology & Diagnostic Services (BioVed) RESEARCH INTERESTS • Microbial and eukaryotic genomics • Vaccine development – humoral and cellular immunity • Vector biology and host-pathogen interactions RECENT PUBLICATIONS Nene, V., Tick genomics – coming of age. Frontiers in Bioscience. 14, 2666-2673, 2009. Salzberg, S. L., Puiu, D., Sommer, D. D., Nene, V. and Lee, N. H. Genome sequence of the Wolbachia endosymbiont of Culex quinquefasciatus JHB. J. Bacteriol. 191: 1725, 2009. Tinega, A. N., Pelle, R., Kang’a, S., Gicherun, M. M., Taracha, E. L. N., Nene, V. and Graham, S. P. Fusion of a cell penetrating peptide from HIV-1 TAT to the Theileria parva antigen Tp2 enhances the stimulation of bovine CD8+ T cell response. Vet. Immunol. Immunopathol. 2009. In press. Ishmael, N., Dunning Hotopp, J. C., Ioannidis, P., Biber, S, Sakamoto, J., Siozios, S., Nene, V., Werren, J., Bourtzis, K., Bordenstein, S. R. and Tettelin, H. Extensive genomic diversity of closely related Wolbachia strains. Microbiology. 2009. In press. Sunter, J. D., Patel, S. P., Skilton, R. A., Githaka, N., Knowles, D. P., Scoles, G. R., Nene, V., de Villiers, E., and Bishop, R. P. A novel SINE family occurs frequently in both genomic DNA and transcribed sequences in ixodid ticks of the arthropod sub-phylum Chelicerata. Gene 415:13-22, 2008. Guerrero, F. D. and Nene, V. Gene structure and expression of a pyrethroid-metabolizing esterase, CzEst9, from a pyrethroid resistant Mexican population of Rhipicephalus (Boophilus) microplus (Arcari:Ixodidae). J. Med. Entomology 45: 677-685, 2008. Guerrero, F. D., Dowd, S. E., Nene, V. M. and Foil, L.D. Expressed cDNAs from embryonic and larval stages of the Horn Fly (Diptera: Muscidae). J. Med. Entomology 45: 686-692, 2008. Guerrero, F.D., Wang, M., Nene, V.M., Dowd, S.E. and Saldivar, L. EST-based gene indices for the cattle fever tick, the horn fly, and the screwworm fly. Dev. Biol. 132: 115-120, 2008. Carlton, J. M., Adams, J., Silva, J. C., Bidwell, S. L., Lorenzi, H., Caler, E., LaCount, D., Date, S. V., Crabtree, J., Angiuoli, S.V., Merino, E. F., Amedeo, P., Cheng, Q., Chettier, R., Coulson, R. M. R., Crabb , B. S., del Portillo, H. A., Essien, K., Feldblyum, T. V., Fernandez-Becerra, C., Fields, S., Gilson, P. R., Gueye, A. H., Guo, X., Hughes, R., Kang’a, S., Kooij, T. W. A., Korsinczky, M., Kurschner, C., Meyer, E, V-S., Nene, V., Paulsen, I., White, O., Ralph, S. A., Ren, Q., Sargeant, T. J., Sahasrabudhe, S., Salzberg, S., Schoenfeld, L. W., Stoeckert, C. J., Sullivan, S. A., Vignali, M., Yamamoto, M. M., Hoffman, S. L., Wortman, J. R., Gardner, M. J., Galinski, M., Barnwell, J. W. and Fraser-Liggett, C. M. Comparative genomics of the neglected human parasite Plasmodium vivax illuminates malaria parasite biology. Nature. 455: 757-763, 2008. Desjardins, C. A., Gundersen-Rindal, D. E., Hostetler, J. B., Tallon, L. J., Fadrosh, D. W., Fuester, R. W., Pedroni, M. J., Haas, B. J., Schatz, M. C., Jones, K. M., Crabtree, J., Forberger, H., and Nene, V. Comparative genomics of mutualistic viruses of Glyptapanteles parasitic wasps. Genome Biology. 9: R183, 2008. Guerrero, F.D., Bendele, K.G., Chen, A.C., Li, A.Y., Miller, R.J., Pleasance, E., Varhol, R., Rousseau, M-E. and Nene, V.M. Serial analysis of gene expression in the southern cattle tick following acaricide treatment of larvae from organophosphate resistant and susceptible strains. Insect Mol. Biol. 16: 49-60, 2007. Graham, S. P, Saya, R., Awino, E., Ngugi, D., Nyanjui, J.K. Kecker, R., Taracha, E. L. N. and Nene, V. Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva. Vet. Immunol. Immunopath. 115: 383-389, 2007. Graham, S. P., Honda, Y., Pelle, R., Mwangi, D. M., Glew, J., de Villiers, E. P., Shah, T., Bishop, R., van der Bruggen, P., Nene, V., Taracha, E. L. N. A novel strategy for the identification of cytotoxic T lymphocyte target antigens from genomic data. Immunome Res. 3: 2, 2007. Danley, P. D., Mullen, S. P., Lui, F., Nene, V., Quackenbush, J. and Shaw, K. L. A cricket gene index: a neurological, behavioral and evolutionary genetic resource. BMC Genomics 8: 109, 2007. Nene, V., Wortman, J. R., Lawson, L., Haas, B., Kodira, C., Tu, Z., Loftus, B., Xi, Z., Megy, K., Grabherr, M., Ren, Q., Zdobnov, E. M., Lobo, N. F., Campbell, K. S., Brown, S. E., Bonaldo, M. F., Zhu, J., Sinkins, S. P., Hogenkamp, D. G., Amedo, P., Arensburger, P., Atkinson, P. W., Bidwell, S., Biedler, J., Birney, E., Bruggner, R. V., Costas, J., Coy, M R., Crabtree, J., Crawford, M., deBruyn, B., DeCaprio, D., Eiglmeier, K., Eisenstadt, E., El-Dorry, H., Gelbart, W. M., Gomes, S. L., Hammond, M., Hannick, L. I., Hogan, J. R., Holmes, M. H., Jaffe, D., Johnston, S. J., Kennedy, R. C., Koo, H., Kravitz, S., Kriventseva, E. V., Kulp, D., LaButti, K., Lee, E., Li, S., Lovin, D. D., Mao, C., Mauceli, E., Menck, C. F. M., Miller, J. R., Montgomery, P., Mori, A., Nascimento, A. L., Naveira, H. F., Nusbaum, C., O’Leary, S. B., Orvis, J., Pertea, M., Quesneville, H., Reidenbach, K. R., Rogers, Y-H., Roth, C. W., Schneider, J. R., Schatz, M., Shumway, M., Stanke, M., Stinson, E. O., Tubio, J. M. C., VanZee, J. P., Verjovski-Almeida, S., Werner, D., White, O., Wyder, S., Zeng, Q., Zhao, Q., Zhao, Y., Hill, C. A., Raikhel, A. S., Soares, M. B., Knudson, D. L., Lee, N. H., Galagan, J., Salzberg, S. L., Paulsen, I. T., Dimopoulos, G., Collins, F. H., Birren, B., Fraser-Liggett, C. M. and Severson, D. W. , Genome sequence of Aedes aegypti, a major arbovirus vector. Science, May 17 2007 (10.1126/science.1138878). Desjardins, C., Gundersen-Rindal, D., Hostetler, J.,B., Tallon, L. J., Fuester, R. W., Schatz, M., Pedroni, M. J., Fadrosh, D. W., Haas, B. J., Toms, B. S., Chen, D and Nene, V. Structure and evolution of a proviral locus of Glyptapanteles indiensis bracovirus. BMC Microbiol. 7: 61, 2007. Van Zee, J. P., N.S. Geraci, N. S., Guerrero, F. D., Wikel, S. K., Stuart, J. J., Nene, V. M. and Hill, C. A. Tick genomics: The Ixodes genome project and beyond. Int. J. Parasitol. 37, 1297-1305, 2007. Jongejan, F., Nene, V., de la Fuente, J., Pain, A. and Willadsen, P. Advances in the genomics in ticks and tick-borne pathogens. Trends Parasitol. 23, 391-396, 2007. Wang, M., Guerrero, F. D., Pertea, G. and Nene, V. Global comparative genomic analysis of the southern cattle tick, Rhipicephalus (Boophilus) microplus. BMC Genomics 12: 368, 2007. Baryon, K.A., Lau, A.O., Herndon, D.R., Hannick, L., Kappmeyer, L.S., Berens, S.J., Bidwell, S.L., Brown, W.C., Crabtree, J., Fadrosh, D., Feldblum, T., Forberger, H.A., Haas, B.J., Howell, J.M., Khouri, H., Koo, H., Mann, D.J., Norimine, J., Paulsen, I.T., Radune, D., Ren, Q., Smith, R.K., Suarez, C.E., White, O., Wortman, J.R., Knowles, D.P., McElwain, T.F. and Nene, V. M. PLoS Patho. Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa. 3:e148, 2007.
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